Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation

Abstract excerpt

It has recently been shown that the transcription factor Erg, an Ets family member, drives constitutive expression of the intercellular adhesion molecule 2 (ICAM-2) in human umbilical vein endothelial cells (HUVECs) and that its expression is down-regulated by the pleiotropic cytokine tumor necrosis factor alpha (TNF-alpha). To identify other Erg target genes and to define its function in the endothelium, a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Angiogenesis and VEGF in Cancer
• Share to Atherosclerosis and Cardiovascular Diseases
• Share to Cell Adhesion Molecules Research