Article

Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge

2023-02-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> During infectious diseases, pro-inflammatory cytokines transiently destabilize interactions between adjacent vascular endothelial cells (ECs) to facilitate the passage of immune molecules and cells into tissues. However, in the lung the resulting vascular hyperpermeability can lead to organ dysfunction. Previous work identified the transcription factor ERG as a master regula...

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Literature Corpus work: 9ee21c50-92a4-50a4-a055-8b218027d953
DOI: 10.1101/2023.02.08.527788

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