Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus.

Current biology : CB - 13 Nov 2001

Massey R C, Buckling A, Peacock S J

Abstract excerpt

Bacterial antibiotic resistance is often associated with a fitness cost in the absence of the antibiotic [1,2]. We have examined a resistance mechanism in Staphylococcus aureus that negates these costs. Exposure to gentamicin both in vitro and in vivo has been reported to result in the emergence of a gentamicin-resistant small colony variant (SCV)[3-8]. We show that the emergence of SCVs following exposure to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Anti-Bacterial Agents
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gentamicins

Share to Phenotype

Share to Staphylococcal Infections

Share to Staphylococcus aureus

Share to Streptomycin

Source

Identifiers

PMID: 11719226
DOI: 10.1016/s0960-9822(01)00507-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic switching of antibiotic resistance circumvents permanent costs in Staphylococcus aureus.PMID 11719226Read ↗

Phenotype switching is a natural consequence of Staphylococcus aureus replication.Semantic proximity Read ↗

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureusSemantic proximity Read ↗

Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infectionSemantic proximity Read ↗

Fitness Cost of Antibiotic Resistance in Staphylococcus aureus: A Systematic Review.Semantic proximity Read ↗

Phenotypic and genetic changes in the life cycle of small colony variants of Salmonella enterica serotype Typhimurium induced by streptomycin.Semantic proximity Read ↗

The Evolution of Heteroresistance via Small Colony Variants in <i>Escherichia coli</i> Following Long Term Exposure to Bacteriostatic AntibioticsSemantic proximity Read ↗

Reversible Antibiotic Tolerance Induced in Staphylococcus aureus by Concurrent Drug ExposureSemantic proximity Read ↗

Role of antibiotic stress in phenotypic switching to persister cells of antibiotic-resistant Staphylococcus aureusSemantic proximity Read ↗

Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.Semantic proximity Read ↗

Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge.Semantic proximity Read ↗

Adaptation to the fitness costs of antibiotic resistance in Escherichia coli.Semantic proximity Read ↗

Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of BacteremiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.