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Article

Interactions of vitamin D and the proximal tubule.

Pediatric nephrology (Berlin, Germany) - 1 Jan 2016

Chesney Russell W

Abstract excerpt

Severe vitamin D deficiency (reduction in serum 25(OH)D concentration) in infants and children can cause features of the Fanconi syndrome, including phosphaturia, glycosuria, aminoaciduria, and renal tubular acidosis. This indicates that vitamin D and its metabolites influence proximal tubule function. Filtered 25(OH)D bound to vitamin D binding protein (DBP) is endocytosed by megalin-cubilin in the apical...

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Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Share to Fibroblast Growth Factor-23
Share to Kidney Tubules, Proximal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Low Density Lipoprotein Receptor-Related Protein-2

Share to Receptors, Calcitriol

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Share to Vitamin D Deficiency

Share to Vitamin D3 24-Hydroxylase

Source

Identifiers

PMID: 25618772
DOI: 10.1007/s00467-015-3050-5

Genes

DBP
FGF23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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