Article
Translational regulation is a control point in RUNX2/Cbfa1 gene expression.
Biochemical and biophysical research communications - 30 Nov 2001
Sudhakar S, Li Y, Katz M S, Elango N
Abstract excerpt
Runt-related transcription factor-2 (RUNX2)/core binding factor a1 (Cbfa1) is implicated in the regulation of osteoblast differentiation and osteoblast-specific gene expression. Mutations in RUNX2 cause the bone disease cleidocranial dysplasia, which is characterized by multiple skeletal defects. RUNX2 is expressed as two isoforms (type-I and type-II) encoded by two different mRNAs. We report here the detection...
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