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Article

Induction of hepatitis C virus E1 envelope protein-specific immune response can be enhanced by mutation of N-glycosylation sites.

Journal of virology - 1 Dec 2001

Fournillier A, Wychowski C, Boucreux D, Baumert T F, Meunier J C, Jacobs D, Muguet S, Depla E, Inchauspé G

Abstract excerpt

Deglycosylation of viral glycoproteins has been shown to influence the number of available epitopes and to modulate immune recognition of antigens. We investigated the role played by N-glycans in the immunogenicity of hepatitis C virus (HCV) E1 envelope glycoprotein, a naturally poor immunogen. Eight plasmids were engineered, encoding E1 protein mutants in which the four N-linked glycosylation sites of the...

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Identifiers

PMID: 11711599
DOI: 10.1128/JVI.75.24.12088-12097.2001
PMCID: PMC116104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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