Article
The influence of N-linked glycosylation on the antigenicity and immunogenicity of rubella virus E1 glycoprotein.
Virology - 1 Oct 1992
Qiu Z, Tufaro F, Gillam S
Abstract excerpt
Rubella virus E1 glycoprotein contains three functional N-linked glycosylation sites. The role of N-linked glycosylation on the antigenicity and immunogenicity of E1 glycoprotein was studied using vaccinia recombinants expressing E1 glycosylation mutants. Expressed E1 glycosylation mutant proteins were recognized by a panel of E1-specific monoclonal antibodies in radioimmunoprecipitation, immunofluorescence, and...
Topics
- Animals
- Antibodies, Viral
- Antigens, Viral
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Glycosylation
- Mice
- Microscopy, Fluorescence
- Mutation
- Protein Conformation
- Recombinant Proteins