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Article

NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway.

Genes & development - 15 Nov 2001

Frank-Vaillant M, Marcand S

Abstract excerpt

In the yeast Saccharomyces cerevisiae, DNA double strand break (DSB) repair by nonhomologous end-joining (NHEJ) requires the DNA end-binding heterodimer Yku70p-Yku80p and the ligase Dnl4p associated with its cofactor Lif1p. NHEJ efficiency is down-regulated in MATa/MATalpha cells relative to MATa or MATalpha cells, but the mechanism of this mating type regulation is unknown. Here we report the identification of...

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Identifiers

PMID: 11711435
DOI: 10.1101/gad.206801
PMCID: PMC312823

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Source receipt: pubmed, retrieved 7 Sept 2026.

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