Article
Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia.
American journal of medical genetics - 1 Oct 2001
Arango D, Cruts M, Torres O, Backhovens H, Serrano M L, Villareal E, Montañes P, Matallana D, Cano C, Van Broeckhoven C, Jacquier M
Abstract excerpt
Nearly all mutations in the presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid beta precursor protein (APP) genes lead to early-onset Alzheimer disease (EOAD, onset age at or before 65 years). In order to assess the genetic contribution of these genes in a series of Colombian AD cases, we performed a systematic mutation analysis in 11 autosomal dominant, 23 familial, and 42 sporadic AD patients (34% with age...
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