Article
Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies.
Gut - 1 Dec 2001
Silverberg M S, Daly M J, Moskovitz D N, Rioux J D, McLeod R S, Cohen Z, Greenberg G R, Hudson T J, Siminovitch K A, Steinhart A H
Abstract excerpt
BACKGROUND: Linkage data have now identified several inflammatory bowel disease (IBD) susceptibility loci but these data have not been consistently replicated in independent studies. One potential explanation for this is the possibility that patients enrolled in such studies may have been erroneously classified with respect to their diagnosis. AIMS: To determine the rate and type of misclassification in a large...
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