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Article

A MATE family multidrug efflux transporter pumps out fluoroquinolones in Bacteroides thetaiotaomicron.

Antimicrobial agents and chemotherapy - 1 Dec 2001

Miyamae S, Ueda O, Yoshimura F, Hwang J, Tanaka Y, Nikaido H

Abstract excerpt

We cloned a gene, bexA, that codes for a multidrug efflux transporter from the chromosomal DNA of Bacteroides thetaiotaomicron ATCC 29741 by using an Escherichia coli DeltaacrAB DeltaacrEF mutant as a host. Although the initial recombinant construct contained other open reading frames, the presence of bexA alone was sufficient to confer to the E. coli host elevated levels of resistance to norfloxacin,...

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Identifiers

PMID: 11709306
DOI: 10.1128/AAC.45.12.3341-3346.2001
PMCID: PMC90835

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