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Article

Effect of phospholipids on conformational structure of bovine pancreatic trypsin inhibitor (BPTI) and its thermolabile mutants.

Biopolymers - 1 Oct 2008

Izumikawa Naoshige, Nishikori Shingo, Vestergaard Mun'delanji, Hamada Tsutomu, Hagihara Yoshihisa, Yumoto Noboru, Shiraki Kentaro, Takagi Masahiro

Abstract excerpt

The effects of negatively charged phosphatidylserine-prepared membranes (PS) and neutral phosphatidylcholine-prepared membranes (PC) on the structure of wild-type and mutant bovine pancreatic trypsin inhibitor (BPTI) at neutral pH were investigated. The presence of PC did not have any effect on the protein structure while PS induced a non-native structure in three mutant BPTI proteins. However, the negatively...

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PMID: 18521887
DOI: 10.1002/bip.21029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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