Evidence that androgens are the primary steroids produced by <i>Xenopus laevis</i> ovaries and may signal through the classical androgen receptor to promote oocyte maturation

Abstract excerpt

Steroid-induced maturation of Xenopus oocytes has long served as a model for studying meiosis. Progesterone has been considered the relevant steroid controlling maturation, perhaps through interactions with classical progesterone receptors. In this study, we provide evidence that androgens, rather than progesterone, are the physiologic mediators of Xenopus oocyte maturation. Androgens were equal or more potent...

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