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Article

The classical progesterone receptor mediates <i>Xenopus</i> oocyte maturation through a nongenomic mechanism

24 Oct 2000

Abstract excerpt

Xenopus laevis oocytes are physiologically arrested at G(2) of meiosis I. Resumption of meiosis, or oocyte maturation, is triggered by progesterone. Progesterone-induced Xenopus oocyte maturation is mediated via an extranuclear receptor and is independent of gene transcription. The identity of this extranuclear oocyte progesterone receptor (PR), however, has remained a longstanding problem. We have isolated the...

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PMID: 11050156
DOI: 10.1073/pnas.220302597

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