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Fertilization and early embryology: The effect of testosterone on the maturation and developmental capacity of murine oocytes in vitro

1 Sept 1995

Abstract excerpt

A dose-dependent inhibition of meiotic maturation and embryonic development was observed in both cumulus-enclosed and cumulus-denuded murine oocytes following incubation in the presence of 10, 20, 40, 60 and 80 microM testosterone for 18 h in vitro. Maturation to metaphase II was enhanced in cumulus-enclosed oocytes following maturation in the presence of human pre-ovulatory mural granulosa cells. However,...

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PMID: 8530669
DOI: 10.1093/oxfordjournals.humrep.a136302

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