Article
cAMP response element-binding protein mediates thrombin-induced proliferation of vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2001
Tokunou T, Ichiki T, Takeda K, Funakoshi Y, Iino N, Takeshita A
Abstract excerpt
Thrombin is a potent mitogen for vascular smooth muscle cells (VSMCs) and plays an important role in the progression of atherosclerosis. Although recent reports have suggested that cAMP response element-binding protein (CREB) is necessary for the survival of neuronal cells, the role of CREB in VSMC proliferation is not determined. We examined the role of CREB in thrombin-induced VSMC proliferation and the effect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.