Mode of action of the ecdysone agonist tebufenozide (RH-5992), and an exclusion mechanism to explain resistance to it.

doi:10.1002/ps.377

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Article

Mode of action of the ecdysone agonist tebufenozide (RH-5992), and an exclusion mechanism to explain resistance to it.

Pest management science - 1 Oct 2001

Retnakaran A, Gelbic I, Sundaram M, Tomkins W, Ladd T, Primavera M, Feng Q, Arif B, Palli R, Krell P

Abstract excerpt

Spruce budworm larvae (Choristoneura fumiferana) upon ingesting tebufenozide (RH-5992) stop feeding and go into a precocious, incomplete molt, leading eventually to death. Like 20-hydroxyecdysone (20E), tebufenozide also acts at the receptor level and transactivates the expression of up-regulated genes but, because of its persistence, the down-regulated genes that are normally expressed in the absence of 20E are...

Topics

Animals
Cell Line
DNA-Binding Proteins
Diptera
Ecdysone
Gene Expression Regulation
Hydrazines
Insect Control
Insect Proteins
Insecticide Resistance
Insecticides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Juvenile Hormones

Lepidoptera

Microscopy, Electron

Molting

Mutation

Phenotype

Receptors, Invertebrate Peptide

Source

Open in PubMed

Identifiers

PMID: 11695189
DOI: 10.1002/ps.377

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