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Article

Mode of action of the ecdysone agonist tebufenozide (RH-5992), and an exclusion mechanism to explain resistance to it.

Pest management science - 1 Oct 2001

Retnakaran A, Gelbic I, Sundaram M, Tomkins W, Ladd T, Primavera M, Feng Q, Arif B, Palli R, Krell P

Abstract excerpt

Spruce budworm larvae (Choristoneura fumiferana) upon ingesting tebufenozide (RH-5992) stop feeding and go into a precocious, incomplete molt, leading eventually to death. Like 20-hydroxyecdysone (20E), tebufenozide also acts at the receptor level and transactivates the expression of up-regulated genes but, because of its persistence, the down-regulated genes that are normally expressed in the absence of 20E are...

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PMID: 11695189
DOI: 10.1002/ps.377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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