Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signaling through Adenylyl Cyclase Is Essential for Hyphal Growth and Virulence in the Pathogenic Fungus<i>Candida albicans</i>

1 Nov 2001

Abstract excerpt

The human fungal pathogen Candida albicans switches from a budding yeast form to a polarized hyphal form in response to various external signals. This morphogenetic switching has been implicated in the development of pathogenicity. We have cloned the CaCDC35 gene encoding C. albicans adenylyl cyclase by functional complementation of the conditional growth defect of Saccharomyces cerevisiae cells with mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal and yeast genetics research
Share to Fungal Infections and Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11694594
DOI: 10.1091/mbc.12.11.3631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signaling through Adenylyl Cyclase Is Essential for Hyphal Growth and Virulence in the Pathogenic Fungus<i>Candida albicans</i>PMID 11694594Read ↗

Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in <i>Candida albicans</i>Semantic proximity Read ↗

The Ras/cAMP/PKA signaling pathway and virulence in <i>Candida albicans</i>Semantic proximity Read ↗

RA domain-mediated interaction of Cdc35 with Ras1 is essential for increasing cellular cAMP level for Candida albicans hyphal development.Semantic proximity Read ↗

CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans.Semantic proximity Read ↗

Multiple roles and diverse regulation of the Ras/cAMP/protein kinase A pathway in Candida albicansSemantic proximity Read ↗

Ras links cellular morphogenesis to virulence by regulation of the MAP kinase and cAMP signalling pathways in the pathogenic fungus <i>Candida albicans</i>Semantic proximity Read ↗

Genome-Wide Transcriptional Profiling of the Cyclic AMP-Dependent Signaling Pathway during Morphogenic Transitions of Candida albicansSemantic proximity Read ↗

Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.Semantic proximity Read ↗

Ras Signaling Gets Fine-Tuned: Regulation of Multiple Pathogenic Traits of Candida albicansSemantic proximity Read ↗

Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade.Semantic proximity Read ↗

Fungal Adenylyl Cyclase Acts As a Signal Sensor and Integrator and Plays a Central Role in Interaction with BacteriaSemantic proximity Read ↗

<i>Candida albicans</i> filamentation does not require the cAMP-PKA pathway in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.