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Article

Pmel17 Initiates Premelanosome Morphogenesis within Multivesicular Bodies

1 Nov 2001

Abstract excerpt

Melanosomes are tissue-specific organelles within which melanin is synthesized and stored. The melanocyte-specific glycoprotein Pmel17 is enriched in the lumen of premelanosomes, where it associates with characteristic striations of unknown composition upon which melanin is deposited. However, Pmel17 is synthesized as an integral membrane protein. To clarify its physical linkage to premelanosomes, we analyzed the...

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Share to Cutaneous Melanoma Detection and Management
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PMID: 11694580
DOI: 10.1091/mbc.12.11.3451

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