Article
The G to C polymorphism at -174 of the interleukin-6 gene is rare in a Southern Chinese population.
Pharmacogenetics - 1 Nov 2001
Zhai R, Liu G, Yang C, Huang C, Wu C, Christiani D C
Abstract excerpt
Interleukin-6 is thought to be involved in the pathogenesis of coal workers' pneumoconiosis. Recently, a functional G to C polymorphism at position -174 of the promoter of the IL-6 gene has been described. We examined the -174 polymorphisms in 259 retired Chinese men from Guangxi province (all retired coal miners). Only one GC heterozygous and no CC homozygous variants were found. Our results suggest that the...
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