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Article

Transgene-mediated post-transcriptional gene silencing is inhibited by 3' non-coding sequences in Paramecium.

Nucleic acids research - 1 Nov 2001

Galvani A, Sperling L

Abstract excerpt

Homology-dependent gene silencing is achieved in Paramecium by introduction of gene coding regions into the somatic nucleus at high copy number, resulting in reduced expression of all homologous genes. Although a powerful tool for functional analysis, the relationship of this phenomenon to gene silencing mechanisms in other organisms has remained obscure. We report here experiments using the T4a gene, a member of...

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Identifiers

PMID: 11691926
DOI: 10.1093/nar/29.21.4387
PMCID: PMC60190

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