RNA polymerase I can mediate expression of CAT and neo protein-coding genes in Trypanosoma brucei.

doi:10.1002/j.1460-2075.1991.tb04903.x

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Article

RNA polymerase I can mediate expression of CAT and neo protein-coding genes in Trypanosoma brucei.

The EMBO journal - 1 Nov 1991

Rudenko G, Chung H M, Pham V P, Van der Ploeg L H

Abstract excerpt

We show that the ribosomal RNA (rRNA) promoter can efficiently direct expression of protein-coding genes in the parasitic protozoan Trypanosoma brucei. The rRNA promoter was characterized by: (i) point mutations at the rRNA transcription initiation site which completely abolished its promoter function in transient CAT transformation assays; (ii) the alpha-amanitin resistance of transcription of rRNA...

Topics

Amanitins
Animals
Base Sequence
Blotting, Northern
Blotting, Southern
Chloramphenicol O-Acetyltransferase
DNA, Protozoan
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

RNA Polymerase I

RNA, Protozoan

Restriction Mapping

Transcription, Genetic

Trypanosoma brucei brucei

Source

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Identifiers

PMID: 1915299
DOI: 10.1002/j.1460-2075.1991.tb04903.x
PMCID: PMC453067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1915299-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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