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Article

A forward genetic screen reveals essential and non-essential RNAi factors in Paramecium tetraurelia.

Nucleic acids research - 1 Jun 2014

Marker Simone, Carradec Quentin, Tanty Véronique, Arnaiz Olivier, Meyer Eric

Abstract excerpt

In most eukaryotes, small RNA-mediated gene silencing pathways form complex interacting networks. In the ciliate Paramecium tetraurelia, at least two RNA interference (RNAi) mechanisms coexist, involving distinct but overlapping sets of protein factors and producing different types of short interfering RNAs (siRNAs). One is specifically triggered by high-copy transgenes, and the other by feeding cells with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24860163
DOI: 10.1093/nar/gku223
PMCID: PMC4066745

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