Article
In vivo modification of Na(+),K(+)-ATPase activity in Drosophila.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology - 1 Dec 2001
Sun B, Xu P, Wang W, Salvaterra P M
Abstract excerpt
We have constructed and characterized transgenic Drosophila lines with modified Na(+),K(+)-ATPase activity. Using a temperature dependent promoter from the hsp70 gene to drive expression of wild-type alpha subunit cDNA, we can conditionally rescue bang-sensitive paralysis and ouabain sensitivity of a Drosophila Na(+),K(+)-ATPase alpha subunit hypomorphic mutant, 2206. In contrast, a mutant alpha subunit...
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