Article
Mutations in the Caenorhabditis elegans Na,K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Dec 1995
Davis M W, Somerville D, Lee R Y, Lockery S, Avery L, Fambrough D M
Abstract excerpt
We have cloned a Na,K-ATPase alpha-subunit gene from Caenorhabditis elegans and discovered that it is identical to the gene eat-6, eat-6 mutations cause feeble contractions and slow, delayed relaxations of pharyngeal muscle. The resting membrane potential of eat-6 mutant pharynxes is consistently depolarized compared to wild-type. The action potentials are smaller, and the return to resting potential is slower....
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