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Article

Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate.

Molecular and cellular biology - 1 Dec 2001

Rébora K, Desmoucelles C, Borne F, Pinson B, Daignan-Fornier B

Abstract excerpt

In Saccharomyces cerevisiae, AMP biosynthesis genes (ADE genes) are transcriptionally activated in the absence of extracellular purines by the Bas1p and Bas2p (Pho2p) transcription factors. We now show that expression of the ADE genes is low in mutant strains affected in the first seven steps of the pathway, while it is constitutively derepressed in mutant strains affected in later steps. Combined with epistasy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11689683
DOI: 10.1128/MCB.21.23.7901-7912.2001
PMCID: PMC99957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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