Article
Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p.
Molecular microbiology - 1 May 2006
Escusa Stéphanie, Camblong Jurgi, Galan Jean-Marc, Pinson Benoît, Daignan-Fornier Bertrand
Abstract excerpt
In response to nutrient limitation, Saccharomyces cerevisiae cells enter into a non-proliferating state termed quiescence. This transition is associated with profound changes in gene expression patterns. The adenine deaminase encoding gene AAH1 is among the most precociously and tightly downregulated gene upon entry into quiescence. We show that AAH1 downregulation is not specifically due to glucose exhaustion...
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