Article
5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2001
Romano M, Catalano A, Nutini M, D'Urbano E, Crescenzi C, Claria J, Libner R, Davi G, Procopio A
Abstract excerpt
Evidence indicates that lipoxygenases (LO) may play a role in cancer cell survival. We show that human malignant pleural mesothelial (MM) cells, but not normal mesothelial (NM) cells, express a catalytically active 5-LO. Pharmacological or genetic inhibition of MM cell 5-LO determined nucleosome formation and induced a DNA fragmentation pattern typical of apoptosis. This was completely reversed by exogenously...
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