Article
Drosophila rab GDI mutants disrupt development but have normal Rab membrane extraction.
Genesis (New York, N.Y. : 2000) - 1 Sept 2001
Ricard C S, Jakubowski J M, Verbsky J W, Barbieri M A, Lewis W M, Fernandez G E, Vogel M, Tsou C, Prasad V, Stahl P D, Waksman G, Cheney C M
Abstract excerpt
Rab GTPases are essential for vesicular transport. Rab GDP dissociation inhibitor (GDI) binds to GDP-bound rabs, removes rabs from acceptor membranes and delivers rabs to donor membranes. We isolated lethal GDI mutations in Drosophila and analyzed their developmental phenotypes. To learn how these mutations affect GDI structure, the crystal structure of Drosophila GDI was determined by molecular replacement to a...
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