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Article

STAT3R152W Mutation Model Reveals Temporal Changes in Hematopoietic Populations.

International journal of molecular sciences - 5 Feb 2026

Jankowski Jakub, Chen Jichun, Lee Sung-Gwon, Liu Chengyu, Young Neal, Hennighausen Lothar

Abstract excerpt

Inconsistent presentation of STAT3 variants in clinical settings makes them challenging to use in diagnostics and the prevention of unfavorable outcomes. Patients harboring the STAT3R152W variant display a range of autoimmune disorders, including type 1 diabetes, hemolytic anemia, and thrombocytopenia. Because of a complex interplay of genetic and environmental cofactors, it is difficult to discern the direct...

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41684006
DOI: 10.3390/ijms27031587
PMCID: PMC12898827

Genes

STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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