Article
Association of amino acid variations in the NS5A and E2-PePHD region of hepatitis C virus 1b with hepatocellular carcinoma.
Journal of viral hepatitis - 1 Jan 2008
Hung C-H, Chen C-H, Lee C-M, Wu C-M, Hu T-H, Wang J-H, Yen Y-H, Lu S-N
Abstract excerpt
NS5A and E2 proteins of the hepatitis C virus (HCV) have the potential to repress protein kinase R (PKR) that exerts a tumour suppressor function. We investigated the relationship between amino acid variations in the NS5A-PKR-binding domain and E2-PKR-eIF2alpha phosphorylation homology domain (PePHD) region and the development of hepatocellular carcinoma (HCC) in chronic HCV-1b patients. In a cross-sectional,...
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