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Article

A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p.

The Journal of biological chemistry - 17 Dec 2004

Shcherbik Natalia, Kee Younghoon, Lyon Nancy, Huibregtse Jon M, Haines Dale S

Abstract excerpt

Proteasome-dependent processing of the endoplasmic reticulum localized transcription factor Spt23p of Saccharomyces cerevisiae generates its transcriptionally competent form and requires the WW domain containing Rsp5p ubiquitin ligase. Although previous studies documented an Rsp5p-Spt23p associat...

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Source

Identifiers

PMID: 15466864
DOI: 10.1074/jbc.M410325200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15466864-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p.PMID 15466864Read ↗

WW domains 2 and 3 of Rsp5p play overlapping roles in binding to the LPKY motif of Spt23p and Mga2p.Semantic proximity Read ↗

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Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.Semantic proximity Read ↗

WW domains of Rsp5p define different functions: determination of roles in fluid phase and uracil permease endocytosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.Semantic proximity Read ↗

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