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Article

Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain.

The Journal of biological chemistry - 14 Dec 2001

Ablooglu A J, Frankel M, Rusinova E, Ross J B, Kohanski R A

Abstract excerpt

Low catalytic efficiency of protein kinases often results from intrasteric inhibition caused by the activation loop blocking the active site. In the insulin receptor's kinase domain, Asp-1161 and Tyr-1162 in the peptide substrate-like sequence of the unphosphorylated activation loop can interact with four invariant residues in the active site: Lys-1085, Asp-1132, Arg-1136, and Gln-1208. Contributions of these six...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11598120
DOI: 10.1074/jbc.M107236200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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