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Cytotoxic Necrotizing Factor Type 1 of Uropathogenic <i>Escherichia coli</i> Kills Cultured Human Uroepithelial 5637 Cells by an Apoptotic Mechanism

1 Oct 2000

Abstract excerpt

Pathogenic Escherichia coli associated with urinary tract infections (UTIs) in otherwise healthy individuals frequently produce cytotoxic necrotizing factor type 1 (CNF1), a member of the family of bacterial toxins that target the Rho family of small GTP-binding proteins. To gain insight into the function of CNF1 in the development of E. coli-mediated UTIs, we examined the effects of CNF1 intoxication on a panel...

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PMID: 10992497
DOI: 10.1128/iai.68.10.5869-5880.2000

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