Article
Normal innervation and differentiation of X-linked myotubular myopathy muscle cells in a nerve-muscle coculture system.
Neuromuscular disorders : NMD - 1 Nov 2001
Dorchies O M, Laporte J, Wagner S, Hindelang C, Warter J M, Mandel J L, Poindron P
Abstract excerpt
To study the pathogenesis of X-linked recessive myotubular myopathy (XLMTM), we used a nerve-muscle coculture system which allows the reconstitution of functional motor units in vitro after coupling of human skeletal muscle cells with embryonic rat spinal cord explants. We used three skeletal muscle cell lines derived from subjects with known mutations in the MTM1 gene (two from embryonic tissues, associated with...
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