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Accelerated telomere shortening in Fanconi anemia fibroblasts – a longitudinal study

7 Sept 2001

Abstract excerpt

Fanconi anemia (FA) is a fatal inherited disease displaying chromosomal instability, disturbances in oxygen metabolism and a high burden of intracellular radical oxygen species. Oxygen radicals can damage DNA including telomeric regions. Insufficient repair results in single strand breaks that can induce accelerated telomere shortening. In a longitudinal study we demonstrate that telomeric DNA is continuously...

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Share to Chromosomal and Genetic Variations
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 11591364
DOI: 10.1016/s0014-5793(01)02869-1

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