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Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1

1 Sept 2001

Abstract excerpt

Intraneuronal aggregates of hyperphosphorylated tau proteins, referred to as pathological tau, are found in brain areas of demented patients affected by numerous different neurodegenerative disorders. We previously described a particular biochemical profile of pathological tau proteins in myotonic dystrophy type 1 (DM1). This multisystemic disorder is characterized by an unstable CTG repeat expansion in the...

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PMID: 11590131
DOI: 10.1093/hmg/10.19.2143

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