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Article

Systematic Determination of the Packaging Limit of Lentiviral Vectors

10 Oct 2001

Abstract excerpt

Because of their ability to transduce nondividing cells, human immunodeficiency virus type 1 (HIV)-based vectors have great potential for the therapeutic delivery of genes to cells. We describe here a systematic study of the packaging limit of HIV-based vectors. Restriction endonuclease-generated bacterial chromosomal DNA fragments of different lengths were cloned at three different positions within a lentiviral...

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PMID: 11589831
DOI: 10.1089/104303401753153947

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