Article
Can correlated mutations in protein domain families be used for protein design?
Briefings in bioinformatics - 1 Sept 2001
Nagl S B
Abstract excerpt
Evidence from diverse studies, such as protein design experiments and analysis of the emergence of drug resistance in human immunodeficiency virus 1 (HIV-1), indicates that protein function can be diminished or altered by mutations at positions distant from the classic 'functional' site. Furthermore, results from correlation analysis of the ligand-binding domain of nuclear receptors suggest that mutation events...
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