Article
Fibroblast growth factor reversal of the corneal myofibroblast phenotype.
Investigative ophthalmology & visual science - 1 Oct 2001
Maltseva O, Folger P, Zekaria D, Petridou S, Masur S K
Abstract excerpt
PURPOSE: Keratocytes give rise to fibroblasts and myofibroblasts in wounded cornea. It is well established that treatment of fibroblasts with transforming growth factor (TGF) beta will induce myofibroblast differentiation. We investigated whether this differentiation could be reversed by the administration of fibroblast growth factor (FGF). METHODS: Cultured corneal myofibroblasts were plated at 200 cells/mm(2),...
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