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Article

New Androgen Response Elements in the Murine Pem Promoter Mediate Selective Transactivation

1 Oct 2001

Abstract excerpt

The Pem homeobox transcription factor is expressed under androgen control in the testis and epididymis. It is also transcribed in the ovary, muscle, and placenta. The mouse Pem gene promoter was cloned and sequenced. It was analyzed in transactivation tests using CV-1 and PC-3 cells expressing the AR and found to be strongly stimulated by androgens. EMSAs and mutational analysis of the Pem promoter allowed the...

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Identifiers

PMID: 11579212
DOI: 10.1210/mend.15.10.0708

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