Article
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.
The Journal of biological chemistry - 30 Nov 2001
Samuel T, Weber H O, Rauch P, Verdoodt B, Eppel J T, McShea A, Hermeking H, Funk J O
Abstract excerpt
In response to DNA damage and genotoxic stress, the p53 tumor suppressor triggers either cell cycle arrest or apoptosis. The G(2) arrest after damage is, in part, mediated by the p53 target, 14-3-3final sigma (final sigma). Colorectal tumor cells lacking final sigma are exquisitely sensitive to DNA damage. Here we analyzed the mechanism of this sensitivity in final sigma(-/-) as compared with final sigma(+/+)...
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