Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of functional domains of the SMN protein in vivo.

The Journal of biological chemistry - 30 Nov 2001

Wang J, Dreyfuss G

Abstract excerpt

The Survival of Motor Neurons (SMN) is the disease gene of spinal muscular atrophy. We have previously established a genetic system based on the chicken pre-B cell line DT40, in which expression of SMN protein is regulated by tetracycline, to study the function of SMN in vivo. Depletion of SMN protein is lethal to these cells. Here we tested the functionality of mutant SMN proteins by determining their capacity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP Response Element-Binding Protein
Share to Epitopes
Share to Glycine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Precipitin Tests

Share to Retroviridae

Share to RNA-Binding Proteins

Share to SMN Complex Proteins

Share to Tyrosine

Source

Identifiers

PMID: 11572858
DOI: 10.1074/jbc.M105059200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of functional domains of the SMN protein in vivo.PMID 11572858Read ↗

Analysis of mutations in the tudor domain of the survival motor neuron protein SMN.Semantic proximity Read ↗

SMA mutations in SMN Tudor and C-terminal domains destabilize the protein.Semantic proximity Read ↗

Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila.Semantic proximity Read ↗

Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complexSemantic proximity Read ↗

Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila.Semantic proximity Read ↗

The Gemin associates of survival motor neuron are required for motor function in Drosophila.Semantic proximity Read ↗

Composition of the Survival Motor Neuron (SMN) complex in <i>Drosophila melanogaster</i>Semantic proximity Read ↗

Gemins modulate the expression and activity of the SMN complexSemantic proximity Read ↗

A non-sequence-specific requirement for SMN protein activity: the role of aminoglycosides in inducing elevated SMN protein levelsSemantic proximity Read ↗

Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells.Semantic proximity Read ↗

Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye developmentSemantic proximity Read ↗

Decreased function of survival motor neuron protein impairs endocytic pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.