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Article

Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila.

FEBS letters - 8 Dec 2000

Miguel-Aliaga I, Chan Y B, Davies K E, van den Heuvel M

Abstract excerpt

Spinal muscular atrophy is a neurodegenerative disorder caused by mutations or deletions in the survival motor neuron (SMN) gene. We have cloned the Drosophila ortholog of SMN (DmSMN) and disrupted its function by ectopically expressing human SMN. This leads to pupal lethality caused by a dominant-negative effect, whereby human SMN may bind endogenous DmSMN resulting in non-functional DmSMN/human SMN...

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Source

Identifiers

PMID: 11113446
DOI: 10.1016/s0014-5793(00)02243-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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