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Article

A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.

Oncogene - 6 Sept 2001

Rizos H, Puig S, Badenas C, Malvehy J, Darmanian A P, Jiménez L, Milà M, Kefford R F

Abstract excerpt

The INK4a/ARF locus encodes the cyclin dependent kinase inhibitor, p16(INK4a) and the p53 activator, p14ARF. These two proteins have an independent first exon (exon 1alpha and exon 1beta, respectively) but share exons 2 and 3 and are translated in different reading frames. Germline mutations in this locus are associated with melanoma susceptibility in 20-40% of multiple case melanoma families. Although most of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor Protein p14ARF

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Source

Identifiers

PMID: 11571653
DOI: 10.1038/sj.onc.1204728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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