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Article

Mutations in the listerial proB gene leading to proline overproduction: effects on salt tolerance and murine infection.

Applied and environmental microbiology - 1 Oct 2001

Sleator R D, Gahan C G, Hill C

Abstract excerpt

The observed sensitivity of Listeria monocytogenes to the toxic proline analogue L-azetidine-2-carboxylic acid (AZ) suggested that proline synthesis in Listeria may be regulated by feedback inhibition of gamma-glutamyl kinase (GK), the first enzyme of the proline biosynthesis pathway, encoded by the proB gene. Taking advantage of the Epicurian coli mutator strain XL1-Red, we performed random mutagenesis of the...

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Identifiers

PMID: 11571156
DOI: 10.1128/AEM.67.10.4560-4565.2001
PMCID: PMC93203

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