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Article

amiA is a negative regulator of acetamidase expression in Mycobacterium smegmatis.

BMC microbiology - 1 Jan 2001

Parish T, Turner J, Stoker N G

Abstract excerpt

BACKGROUND: The acetamidase of Mycobacterium smegmatis is a highly inducible enzyme. Expression of this enzyme is increased 100-fold when the substrate acetamide is present. The acetamidase gene is found immediately downstream of three open reading frames. Two of these are proposed to be involved in regulation. RESULTS: We constructed a deletion mutant in one of the upstream ORFs (amiA). This mutant (Mad1) showed...

Topics

Amidohydrolases
Bacterial Proteins
Carrier Proteins
Gene Expression Regulation, Enzymologic
Lipoproteins
Mutation
Mycobacterium smegmatis
Promoter Regions, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11570974
DOI: 10.1186/1471-2180-1-19
PMCID: PMC56589

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