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Article

Regulation of Cutaneous Malignancy by γδ T Cells

19 Oct 2001

Abstract excerpt

The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human...

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PMID: 11567106
DOI: 10.1126/science.1063916

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