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Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer

29 Nov 2017

Abstract excerpt

Mouse papillomavirus has shown broad tissue tropism in nude mice. Previous studies have tested cutaneous infections in different immunocompromised and immunocompetent mouse strains. In the current study, we examined mucosal infection in several immunocompetent and immunocompromised mouse strains. Viral DNA was monitored periodically by Q-PCR of lavage samples. Immunohistochemistry and in situ hybridization were...

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PMID: 29208932
DOI: 10.1038/s41598-017-17089-4

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