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Article

Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses

8 Mar 2018

Abstract excerpt

Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas (cSCCs) that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic immunosuppression following organ transplantation. The E6 proteins of the prototypical cutaneous human papillomavirus (HPV) 5 and HPV8 inhibit TGF-ß and NOTCH...

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PMID: 29568286
DOI: 10.3389/fmicb.2018.00389

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